What to look for in a knife handle is a question whose answer—as with most things knife—depends on many factors.
For one thing, no one knife handle fits everyone. Hands come in all shapes and sizes, so a knife handle that will fit a large hand probably will not fit a small one—and vice versa. As a result, no matter how much a knife handle is touted as being “user friendly,” you can't know if it will suit your needs unless you pick the knife up and use it. Of course, that's hard to do when you can't use the knife unless you buy it. Then, if you don't like the knife, you're stuck with it.
One way around that is to find a friend who has the knife in question and borrow it. Of course, you will need to take good care of the knife and give it back when you're through.
Barring the above, look for a knife handle with gentle curves, contours and palm swells that fit the shape of your palm snugly. This will help prevent the knife from sliding around in your hand or cause you to have to constantly regrip the knife handle with your hand. Avoid finger grooves as they are too restrictive in terms of the way you can hold a knife handle. Besides, you may find over time that grooves you thought fit your fingers/hand really don't.
Avoid a knife handle that has sharp corners at the butt or any place that tend to dig into your hand. Those can cause hot spots or even cut you. Avoid a knife handle that is too soft. It may feel good at first but it, too, can cause hot spots/friction on your palm and/or fingers over extended periods of use.
Single, integral guards are good as they keep your hand from sliding onto the blade. That's one of the good things about flipper folders—not only do the flippers ease the job of opening the knife but they also serve as single guards.
For more on the best knife handle for you, see your local knife retailer and ask him to show you the many different options you have when it comes to a knife handle.
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